- Salvage Yards, Junk Yards & Wrecker Service, Newcomerstown
- Sandwich Shop Restaurants, Newcomerstown
- Satellite & Cable TV Equipment & Systems Repair & Service, Newcomerstown
- Sawmill & Planing Mills, Newcomerstown
- Sawmill Supplies & Equipment Repair, Newcomerstown
- Seeds & Bulbs Wholesale & Growers, Newcomerstown
- Senior Citizen Counseling, Newcomerstown
- Senior Citizens Service & Health Organizations, Newcomerstown
- Septic Tanks & Septic Systems Contractors, Newcomerstown - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Shopping & Shopping Services, Newcomerstown
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- Snacks & Desserts, Newcomerstown
- Social Services & Welfare, Newcomerstown
- Special Dies Tools Jigs & Fixtures Manufacturers, Newcomerstown
- Speciality Food Stores, Newcomerstown
- Specialty Stores, Newcomerstown
- Sports Medicine, Newcomerstown - Doctors, Physicians & Surgeons
- Sportswear Clothing Stores, Newcomerstown - Sports Clothes
- State Government, Newcomerstown
- Stone, Newcomerstown
- Stoves & Furnace Equipment, Newcomerstown - Fittings & Repair Parts
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