- Sales & Marketing Consultant, East Palestine
- Sandwich Shop Restaurants, East Palestine
- Seafood Restaurants, East Palestine
- Secondary Schools, East Palestine
- Septic Tanks & Systems, East Palestine - Wholesale, Dealers & Suppliers
- Shoe Repair Shops, East Palestine
- Shoe Stores, East Palestine - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, East Palestine
- Snacks & Desserts, East Palestine
- Social Services & Welfare, East Palestine
- Societies & Foundation Associations, East Palestine
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- Sororities, East Palestine
- Specialty Stores, East Palestine
- Sporting Goods Equipment Rental, East Palestine
- Sporting Goods Stores, East Palestine
- Sports Medicine, East Palestine - Doctors, Physicians & Surgeons
- Sportswear Manufacturers, East Palestine
- Sportswear Wholesale, East Palestine
- State Government, East Palestine
- Steel & Metal Goods, East Palestine - Steel Distributors
- Steel Manufacturers, East Palestine
- Steel Mills & Blast Furnaces, East Palestine
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