- Salvage Yards, Junk Yards & Wrecker Service, Brookville
- Sand Gravel & Aggregate, Brookville
- Sandwich Shop Restaurants, Brookville
- Satellite Dish Antennas & Equipment Dealers, Brookville
- Scrap & Waste Materials, Brookville
- Scrapbooks & Scrapbook Supplies, Brookville
- Seafood Restaurants, Brookville
- Sealcoating, Brookville - Asphalt Sealcoating & Paving
- Secondary Schools, Brookville
- Security Alarm Systems - Home & Business, Brookville
- Security Brokers & Dealers, Brookville
- Security Services, Brookville
- Sewer & Drain Cleaning & Repair, Brookville - Drain Cleaner & Installation Services
- Sewer Construction Contractors, Brookville - Sewer Line, Pipe Installation & Repair Services
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- Shoe Store - More, Brookville
- Shoe Stores, Brookville - Mens, Womens & Kids Shoes
- Shooting & Target Ranges, Brookville
- Shopping & Shopping Services, Brookville
- Snow Removal Services, Brookville - Snow Plow Service
- Social Services & Welfare, Brookville
- Societies & Foundation Associations, Brookville
- Sound Systems, Microphones & Equipment, Brookville
- Specialty Animal Services, Brookville
- Specialty Stores, Brookville
- Steel Manufacturers, Brookville
- Stocks & Bond Brokers, Brookville
- Stoves & Furnace Equipment, Brookville - Fittings & Repair Parts
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