- Sand Gravel & Aggregate, Belpre
- Sandwich Shop Restaurants, Belpre
- Satellite Dish Antennas & Equipment Dealers, Belpre
- Science & Research, Belpre
- Scientific Equipment & Services, Belpre
- Scientific Services, Belpre
- Screen Houses, Belpre
- Secondary Schools, Belpre
- Secretarial & Court Reporting Services, Belpre
- Security Brokers & Dealers, Belpre
- Septic & Cesspool Equipment & Supplies, Belpre
- Septic Tank Pumping & Cleaning, Belpre - Septic Systems
- Septic Tanks & Septic Systems Contractors, Belpre - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Belpre - Wholesale, Dealers & Suppliers
- Sheet Metal, Belpre
- Shipping Terminals, Belpre
- Shopping & Shopping Services, Belpre
- Siding Contractors, Belpre - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Belpre
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- Smoking Cessation Treatment Centers & Information Services, Belpre
- Snack Foods, Belpre
- Social Services & Welfare, Belpre
- Social Workers & Services, Belpre
- Societies & Foundation Associations, Belpre
- Specialty Animal Services, Belpre
- Specialty Communication Companies & Services, Belpre
- Specialty Stores, Belpre
- Sporting Goods Stores, Belpre
- Sports Medicine, Belpre - Doctors, Physicians & Surgeons
- Stamp Collecting & Coin Dealers , Belpre
- Staples Staplers & Tackers, Belpre
- Steel & Metal Goods, Belpre - Steel Distributors
- Stocks & Bond Brokers, Belpre
- Substance Abuse Outpatient Clinics, Belpre
- Support Services, Belpre
- Swimming Pool, Sauna & Spa Contractors, Belpre
- Swimming Pools Contractors, Belpre - Install Inground - Above Ground Pools
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