- Safety & Security Systems & Consultants, Vandalia
- Sales & Marketing Consultant, Vandalia
- Sandwich Shop Restaurants, Vandalia
- Satellite Dish Antennas & Equipment Dealers, Vandalia
- Savings & Loan Associations, Vandalia
- Savings Banks, Vandalia
- Screen Houses, Vandalia
- Seafood Restaurants, Vandalia
- Secondary Schools, Vandalia
- Security & Surveillance System & Equipment, Vandalia
- Security Brokers & Dealers, Vandalia
- Security Consultants, Vandalia
- Security Guard & Patrol Service, Vandalia - Bodyguard, Guard Dogs, Etc
- Security Services, Vandalia
- Semiconductors & Equipment, Vandalia
- Service & Gas Station Equipment & Services, Vandalia
- Service Establishment Supplies & Equipment, Vandalia
- Sewer & Drain Cleaning & Repair, Vandalia - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Vandalia
- Shooting & Target Ranges, Vandalia
- Shopping & Shopping Services, Vandalia
- Siding Contractors, Vandalia - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Vandalia
- Skating Rink & Hockey Operation Services, Vandalia
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- Snacks & Desserts, Vandalia
- Snow Removal Services, Vandalia - Snow Plow Service
- Social Services & Welfare, Vandalia
- Societies & Foundation Associations, Vandalia
- Spare Rib Restaurants, Vandalia
- Specialty Animal Services, Vandalia
- Specialty Communication Companies & Services, Vandalia
- Specialty Stores, Vandalia
- Speech & Hearing Specialists, Vandalia
- Sporting Goods Stores, Vandalia
- Sports Bars & Lounges, Vandalia
- Sports Clubs, Vandalia
- Sprinkler Alarm Systems, Vandalia - Fire Sprinkler Systems
- Staffing & Support Services, Vandalia
- Stamp Collecting & Coin Dealers , Vandalia
- Steak House Restaurants, Vandalia
- Steel & Metal Goods, Vandalia - Steel Distributors
- Steel Manufacturers, Vandalia
- Stocks & Bond Brokers, Vandalia
- Store Fronts, Vandalia - Storefront
- Stoves & Furnace Equipment, Vandalia - Fittings & Repair Parts
- Submarine Sandwich Restaurants, Vandalia
- Substance Abuse Clinics, Vandalia - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Vandalia - Surveying Service
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