- Sandwich Shop Restaurants, New Lexington
- Satellite Descrambling & Programming Service, New Lexington
- Satellite Dish Antennas & Equipment Dealers, New Lexington
- Satellite TV Service, New Lexington
- Sawmill & Planing Mills, New Lexington
- Sawmill Supplies & Equipment Repair, New Lexington
- Scrap & Waste Materials, New Lexington
- Secondary Schools, New Lexington
- Senior Citizens Service & Health Organizations, New Lexington
- Septic Tanks & Septic Systems Contractors, New Lexington - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, New Lexington - Wholesale, Dealers & Suppliers
- Shopping & Shopping Services, New Lexington
- Signs, New Lexington
- Social Clubs & Organizations, New Lexington
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- Social Service Organizations Volunteer Services, New Lexington
- Social Services & Welfare, New Lexington
- Special Education & Care, New Lexington
- Special Needs Transportation, New Lexington
- Specialty Stores, New Lexington
- Sporting Goods Stores, New Lexington
- Sports Bars & Lounges, New Lexington
- State Government, New Lexington
- Steel Manufacturers, New Lexington
- Stoves & Furnace Equipment, New Lexington - Fittings & Repair Parts
- Surveyor Services, New Lexington - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, New Lexington
- Swimming Pools Contractors, New Lexington - Install Inground - Above Ground Pools
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