- Obstetricians & Gynecologists, Middletown - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Occupational Health & Safety, Middletown
- Occupational Health Care Professionals, Middletown
- Occupational Therapy, Middletown - Occupational Health Specialists
- Office Buildings & Parks, Middletown
- Office Supplies, Equipment & Office Furniture Stores, Middletown
- Oil & Petroleum Products, Middletown - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Middletown - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Middletown - Oil Companies
- Oil Petroleum Wholesale, Middletown
- Oils Industrial, Middletown
- Old Age Homes Service, Middletown
- Ophthalmologists, Middletown - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Middletown
- Opticians, Middletown
- Optometrists, Middletown - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Middletown - Dentists - Oral & Maxillofacial Surgeons
- Orchestras, Symphonies & Bands, Middletown
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- Ornamental Nursery, Middletown
- Ornamental Nursery Services, Middletown
- Orthodontist, Middletown - Teeth Straightening, Invisalign & Dental Braces
- Orthodox Churches, Middletown
- Orthopedic & Prosthetic Appliances & Shoes, Middletown - Orthopedic Shoes
- Orthopedists, Middletown - Orthopedic Surgery Doctors, Physicians & Surgeons
- Other Attorneys & Lawyers, Middletown
- Other Attorneys & Lawyers, Middletown
- Other Building Materials & Supplies, Middletown
- Other Electrical Products, Middletown
- Other Industrial Contractors, Middletown
- Other Lawyers & Attorneys, Middletown
- Outdoor & Lawn & Garden Equipment Repair & Service, Middletown
- Outdoor Equipment & Accessories, Middletown
- Outerwear Stores, Middletown - Jackets, Sunglasses, Hats, Caps, Coats, Gloves & More
- Outpatient Clinics, Middletown - Care & Treatment Centers
- Outpatient Services, Middletown - Outpatient Care
- Oxygen & Respiratory Equipment & Supplies, Middletown - Oxygen Concentrator, Tank, Machine, etc
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