- Sales & Marketing Consultant, Fredericktown
- Sand Gravel & Aggregate, Fredericktown
- Sandwich Shop Restaurants, Fredericktown
- Scrap & Waste Materials, Fredericktown
- Sealcoating, Fredericktown - Asphalt Sealcoating & Paving
- Secondary Schools, Fredericktown
- Shopping & Shopping Services, Fredericktown
- Siding Contractors, Fredericktown - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Social Services & Welfare, Fredericktown
- Speciality Food Stores, Fredericktown
- Specialty Animal Services, Fredericktown
- Specialty Stores, Fredericktown
- State Government, Fredericktown
- Steel & Metal Goods, Fredericktown - Steel Distributors
- Stove, Oven, Range & Cooktop Parts & Supplies, Fredericktown
- Submarine Sandwich Restaurants, Fredericktown
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